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I always had good skin until the summer of my senior year in high school. I started using a topical cream and that was effective until December of that year when I started to have moderate break outs. I was prescribed Minocycline and a higher dose of my topical cream. At first I could only use Minocycline once a day, because twice a day would make me dizzy, but I have worked up to 1 and 1/2 pills every day and have no more acne on my skin at all. It is very very effective with a topical cream. In a couple weeks I will try 2 pills a day (which is the dose I am suggested to take) and if I can't handle it, I will stay with 1 and 1/2 pills a day until I can.