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The second phase is a 6-week double-blind acute phase in which the efficacy and tolerability of adjunctive pramipexole and placebo are compared.
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Double the dose with strong CYP3A4 inducers over 1 to 2 weeks.
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Patients with early disease did not receive concomitant levodopa therapy during treatment with Pramipexole; those with advanced Parkinson's disease all received concomitant levodopa treatment.
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This dysfunction disrupts the production of dopamine and may cause the jerky motions of RLS.
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Patients, ages 18 years or older, with a diagnosis of major depression (without psychotic features), will be randomized to the combination of a selective dopaminergic receptor agonist and a SSRI or either drug alone for a period of 6 weeks.
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