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It is obvious that highest plasma level of the drug occurs after the morning peak-incidene of the thromboembolic event, suggesting lower profilactic effect of Aspirin.
IIIa receptor blocker assays, standard-dose clopidogrel (300 mg loading and 75 mg once-daily maintenance) achieves maximally 40% to 50% inhibition of ADP-induced platelet aggregation.
The exclusion criteria were concomitant use of nonsteroidal antiinflammatory drugs (NSAIDs), cyclooxygenase-2 inhibitors, anticoagulant agents, other antiplatelet drugs, or corticosteroids; a history of gastric surgery other than a patch repair; allergy to aspirin or clopidogrel; and the presence of erosive esophagitis, gastric-outlet obstruction, renal failure requiring dialysis, terminal illness, or cancer.
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A generic drug simply means that the drug is not made by the original manufacturer, the chemical is exactly the same.
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See Table 7 for a summary of recommendations from this section.
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