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AHA Task Force on Practice Guidelines (Task Force), charged with developing, updating, and revising practice guidelines for cardiovascular diseases and procedures, directs and oversees this effort.

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There was no interaction between the ABCB1 polymorphism and CYP2C19 loss-of-function variant alleles and the clinical outcome, but the association of two CYP2C19-deficient alleles and either one or two ABCB1 variant alleles was associated with a rate of events that was more than five times the rate among patients with the wild-type genotypes.

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Whether a mortality benefit would emerge in the setting of fibrinolysis without mandatory angiography is the subject of a separate study specifically powered to assess mortality.

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Although there are many environmental and demographic factors that can influence interethnic drug response variability, another reason is that pharmacogenetic allele frequencies can significantly differ between racial and ethnic populations.

These sites were closed, and the administration of study drugs to all patients at those sites was discontinued.

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