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Although acquisition costs are higher for podophyllotoxin than for crude podophyllum preparations, a large multicenter British trial has demonstrated economic advantages for podophyllotoxin.

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Warts can reappear after successful treatment.

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Currently however, the use of podophyllin is almost entirely restricted to the treatment of venereal warts.

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In 1876 Marks Twain's infamous character, Tom Sawyer, contracted warts from playing with frogs and used folkloric treatments to remove them.

Sharma N, Sharma UK, Gupta AP and Sinha AK (2010) Simultaneous determination of epicatechin, syringic acid, quercetin-3-O-galactoside and quercitrin in the leaves of Rhododendron species by using a validated HPTLC method.

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