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I am 33 and have SLE with Raynaulds. I do not have high blood pressure, I am actually on the low side. I took this medicine at 3:30 pm and by 5pm I developed a severe headache, this headache continued all evening and at 9:30pm I was shaking severely, dizzy, and the headache was the worst one I have ever experienced. At that point I started to get very scared. Called my brother over just in case I needed to go to the ER. When he arrived he immediately wanted to call an ambulance. I ended up waiting it out and finally the shaking subsided. The headache still continued the next day, but it was not as severe. The night when everything was going on, I do not remember much of anything. I think from now on I will just keep my blue fingers and toes.
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In man, nifedipine decreases peripheral vascular resistance which leads to a fall in systolic and diastolic pressures, usually minimal in normotensive volunteers (less than 5 to 10 mm Hg systolic), but sometimes larger.
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Patients treated with nifedipine had more distress secondary to shortness of breath, constipation, and tachycardia as opposed to the amlodipine arm which had more distress as a result of thirst and loss of taste ().
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After 10 weeks of treatment there was no significant difference in the mean change of early morning BP between treatment arms.
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Experience in over 1400 patients with PROCARDIA capsules in a noncomparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension, or exacerbation of angina.
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No statistically significant differences were found between nifedipine and transdermal nitroglycerin for delivery within 48 hours of treatment or maternal adverse drug reaction.
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In a subgroup of over 1000 patients receiving nifedipine with concomitant beta blocker therapy, the pattern and incidence of adverse experiences was not different from that of the entire group of nifedipine treated patients.
Heart attackPreliminary evidence suggests that phosphocreatine use may offer benefits for heart attack when combined with nifedipine.
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