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Only a small number of cases of clinically apparent liver disease attributed to pantoprazole have been published, but the clinical pattern of injury has resembled acute hepatic necrosis which has been described with other proton pump inhibitors.

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We petitioned the FDA to require the inclusion of black box warnings identifying the following risks: rebound acid hypersecretion, which results in dependence on these frequently overused drugs; fracture; infection; and magnesium deficiency.

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CK (creatine kinase), generalized edema, elevated triglycerides, liver enzymes elevated myalgia depression, vertigo urticaria, rash, pruritus blurred vision Adverse reaction information in pediatric patients with erosive esophagitis associated with GERD is approved for Wyeth Pharmaceuticals Inc.

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In addition, the ranitidine dose given was greater than that in other studies, and the rate of rebleeding in the ranitidine group was lower than previously reported (3.

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For GERD: "I have been taking this medication for 6 years now religiously every morning.

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In both studies, doses were adjusted to the individual patient need, but gastric acid secretion was controlled in greater than 80% of patients by a starting regimen of 80 mg q12h.

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It's not something I have to take every time I eat or every time I have heartburn or indigestion.

Protonix (pantoprazole) for Erosive Esophagitis: "I just started Protonix 6 days ago.

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Mayo Clinic study in the open access journal Microbiome shows that people who regularly take proton pump inhibitors (PPIs) have less diversity among their gut bacteria, putting them at increased risk for infections like clostridium difficile and pneumonia, in addition to vitamin deficiencies and bone fractures.

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Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa.

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Pantoprazole is used as therapy in GERD, erosive esophagitis, gastritis, gastric ulcerations, duodenal ulcerations and prophylaxis of stress gastritis in hospitalized patients.

In summary, PPI use is associated with the development of FGP.

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