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ISSUE: An FDA review has determined that long-term use of the blood-thinning drug clopidogrel (Plavix) does not increase or decrease overall risk of death in patients with, or at risk for, heart disease.

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ACCP, the American Stroke Association (ASA), and AHA consider clopidogrel an acceptable antiplatelet therapy for secondary prevention of noncardioembolic ischemic stroke or TIAs; other options include aspirin monotherapy, cilostazol, or the combination of aspirin and extended-release dipyridamole.

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