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The study found that at these doses which are two or more times greater than the maximum recommended doses, a dose-related increase in reports of amnesia, sedation, sleepiness, and hallucinations was observed for both eszopiclone (Lunesta) as well as for diazepam ().

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The maximum reductions in diastolic blood pressure for clonidine, tizanidine 12 mg, tizanidine 8 mg, tizanidine 4 mg, and placebo were 19%, 13%, 13%, 7%, and 5%, respectively.

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Too much of this medication can damage your liver.

Although there have been no clinical studies evaluating the effects of other CYP1A2 inhibitors on tizanidine, other CYP1A2 inhibitors, such as zileuton, other fluoroquinolones, antiarrythmics (amiodarone, mexiletine, propafenone and verapamil), cimetidine, famotidine oral contraceptives, acyclovir and ticlopidine, may also lead to substantial increases in tizanidine blood concentrations.

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In postmarketing experience, three deaths associated with liver failure have been reported in patients treated with tizanidine.

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Patients with clinical progression of the syndrome after the first 4 to 6 weeks have, by definition, CIDP.

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Some MEDICINES MAY INTERACT with orphenadrine.

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Shaugnessy, PharmD, Tufts University Family Medicine Residency at Cambridge Health Alliance, Malden, Mass.

Grinspoon is professor emeritus at Harvard University School of Medicine, and the author of numerous publications.

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Dosage is typically initiated at 25 mg, which can be incrementally increased to 100 mg 2 to 4 times per day.

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University of Maryland Medical Center (UMMC).

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