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Because of this property, ursodeoxycholic acid is used to treat (cholesterol) gallstones non-surgically.

Hepatic HMGCoA reductase in human cholelithiasis: Effects of chenodeoxycholic and ursodeoxycholic acids.

What are the possible side effects of ursodiol (Actigall, Urso, Urso Forte)?

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Ursodeoxycholic acid is metabolized in the liver and partially dissolves in the intestine, wherein the conversion of formed enteric toxic 7-keto lithocholic acid, which is slightly absorbed in the bloodstream and in the liver detoxifies.

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Although this study suggested a possible benefit with higher drug doses in resolving liver biochemistry, whether UDCA improves quality of life, histology, or survival is unknown.

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Because vascular effects form an important element of the cancer control evoked by PDT (4), these results suggest that promotion of direct phototoxicity, previously identified in cell culture (1), likely represents the mechanism whereby tumor control is enhanced by UDCA in vivo.

Both clarithromycin and atazanavir are substrates and inhibitors of CYP3A, and there is evidence of a bi-directional drug interaction.

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Drug information on Ursofalk GR (250mg) (Ursodeoxycholic Acid) from German Remedies (Zydus Cadila Healthcare Ltd.

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Changing Therapy for Gallstone Disease.

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Treatment should be stopped if muscle toxicity is suspected clinically (muscle pain, tenderness, or weakness) or if creatine phosphokinase is markedly raised or progressively rising.

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Approximately 20 -30% of clarithromycin is collected as the unchanged parent molecule in the urine.

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The widespread availability of a liquid formulation is needed to facilitate compliance to UDCA therapy particularly in infants and children with cholestatic liver disease that presently have to be given by the parents the powdered contents of commercial UDCA capsules or tablets disguised in some form of food sweetener.

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Extracorporeal shock-wave lithotripsy with ursodiol was more effective than lithotripsy alone for the treatment of symptomatic gallstones, and equally safe.

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FAP familial adenomatous polyposis, APC adenomatous polyposis coli, CR colorectal, IRA ileorectal anastomosism, IPAA ileal pouch-anal anastomosis; Ileostomy: proctocolectomy with ileostomy, UDCA ursodeoxycholic acid, AMC Academic Medical Centre Amsterdam, EMC Erasmus Medical Centre Rotterdam, LUMC Leiden University Medical Centre, RUNMC Radboud University Nijmegen Medical Centre, UMCG University Medical Centre Groningen.