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This was equally true for quinine and plasmoquine, whose action on the plasmodium was indirect.

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Admire the determination of the scientists working in primitive conditions to link the mosquito to the disease.

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Protein binding ranges from 69% to 92% in healthy patients and 78% to 95% in patients with malaria.

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To control it, researchers new to the ranks of the Instituto Soroterapico Federal (renamed the Instituto Oswaldo Cruz in 1908 and also known as the Instituto de Manguinhos) pulled together the knowledge that had been amassed on the disease, creatively adapting it to the realities they encountered in the field.

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