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This may be difficult, particularly in the elderly, malnourished, or people with chronic diseases, whose anemia may be caused by one or more factors.
Fifteen biosimilars are marketed in Europe, five of which have been available since 2007.
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The duration of treatment will be a maximum of 12 months for cumulative dose.
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All EPO samples were desalted and concentrated by a nanosep centrifugal device (Pall Life Sciences, Ann Arbor, USA) using the method described in the Ph.
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Changes in formulation and route of delivery of epoetin products to hemodialysis patients have occurred over time.
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Indeed, elements of the erythrocyte receptor signaling cascade are similar to those of epidermal growth factor (EGF) receptor, a target against which immunotherapeutic agents are being developed (Wakao 1997; Zhang 2006).
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