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The applicability and applicableness of the normal approaches used due to the fact that universality or generalization in physics and the natu- ral sciences are questioned by the interpretive ap- proach, which claims that the point of departure benefit of generalization in clinical grasp cannot be structural or mecha- nistic, but be obliged be based on inferior meanings and practices.

As is the case with current prescription NSAID labels, the Drug Facts labels of over-the-counter (OTC) non-aspirin NSAIDs already contain information on heart attack and stroke risk.

Side effects may include redness or flushing of the skin (which can be reduced by taking aspirin 30 minutes before the niacin), stomach upset (which usually subsides within a few weeks), headache, dizziness, blurred vision, and liver damage.

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Although most studies of MDI versus pump therapy have been small and of short duration, a systematic review and meta-analysis concluded that there were no systematic differences in A1C or rates of severe hypoglycemia in children and adults between the two forms of intensive insulin therapy ().

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Principal Results of the Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS).

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This trial will assess whether an ACE inhibitor (perindopril) has aneurysm-related benefits, in patients with small AAAs at screening centres in the London area.

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CCB combination therapy may have beneficial effects in the management of cardiac ischemia and left ventricular hypertrophy, by limiting inflammation and restoring neurohormonal balance, as well as on fibrinolytic balance and arterial distensibility.

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Fortunately, such decisions and the expert recommendations that seek to guide them can call on evidence from 4 decades of randomized multicenter clinical trials evaluating effects of treatment on clinical CVD.

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The reduction of stroke risk seems to be stronger with a combination of the two drugs.

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Recently, the blood pressure arm of the ADVANCE trial demonstrated that routine administration of a fixed combination of the ACE inhibitor perindopril and the diuretic indapamide significantly reduced combined microvascular and macrovascular outcomes, as well as CVD and total mortality.

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Rare cases of anaphylactoid reactions have been reported in patients undergoing sensitization treatment with hymenoptera (bee, wasp) venom while receiving ACE inhibitors.

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Although the trials included differed somewhat between the meta-analyses and the Lindholm article did not address heart failure, they both concluded that β-blockers were less effective than other major antihypertensive classes in preventing stroke ().

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Post-trial follow-up studies involving patients with diabetes have previously shown long-term beneficial effects of earlier periods of intensive glucose control, but not blood-pressure lowering, on a range of outcomes, including mortality and macrovascular events.

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