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The purpose of the trial was to assess the treatment response and rates of associated severe adverse events with a rituximab-based regimen, as compared with a cyclophosphamide-based regimen, as induction therapy in patients with recently diagnosed, severe ANCA-associated vasculitis, in the hope that a rituximab-based regimen might be more effective and safer.

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Because inflammation is the precursor to fibrosis (scarring), we hope cyclophosphamide will prevent the formation of lung fibrosis and allow the inflamed lung to return to normal.

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