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Power calculations in clinical trials are related to the degree of variability of the drug response phenotypes measured and the treatment difference expected between comparison groups (e.

For example, in some instances, a the microneedle 210 can be inserted through the ciliary body to dispose, at least partially, the distal end portion 212 of the microneedle 210 in the vitreous of, for example, a pediatric eye, as described in further detail herein.

The bevel height H 2 can be any bevel height that prevents piercing of the lens, retina, or choroid when the distal end 412 of the microneedle 410 is inserted through the sclera, and the entire shaft length H" or substantially the entire shaft length H" of the microneedle 410 is inserted into the eye.

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Monoclonal antibody therapy has been associated with the production of human anti-mouse antibodies (HAMA) in 80% of the treated patients and the sensitization rate is 15-40% thus limiting retreatment rates.

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Further, the preclinical datamay include a description of in vivo, in vitro or in silico studies of the biochemical or physiologic effects of a variance or variances (e.

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For recent reviews of systems for high throughput RNA expression analysis see the supplement to volume 21 of Nature Genetics entitled "TheChipping Forecast", especially articles beginning on pages 9, 15, 20 and 25.

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