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Plasma glucose, plasma insulin, and insulin sensitivity.

In the diabetic patients, IGF-binding protein-1 levels increased more than twofold after 2 days of IGF-I infusions, whereas no substantial increase in this binding protein was observed in healthy participants.

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Use of U-500R MDI was associated with significant increase in body weight and TDD, while no significant changes were found in U-500R use via CSII.

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However, if you consume a diet consistently high in sugar and grains, over time your body becomes "sensitized" to insulin and requires more and more of it to get the job done.

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What happens if I miss a dose (Lantus)?