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NSAI, nonsteroidal aromatase inhibitor; ORR, objective response rate; OS, overall survival; PFS, progression-free survival; PR, partial response; PS, performance status; SD, stable disease.
After 528 PFS events, tumor assessments were performed every 12 weeks until disease progression.
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Aim: The objective of this study was to develop nanoparticles of Chondrosia reniformis sponge collagen as penetration enhancers for the transdermal drug delivery of 17β-estradiol-hemihydrate in hormone replacement therapy.
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