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Muscle has a very high dynamic range of demand; and the brain, while reflecting only about 2-4% of (nonobese) body mass, accounts for approximately 20% of oxygen and 50% of glucose utilization.

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It is possible that nigella sativa extract could protect against the development of atherosclerosis, particularly related to the immune system (from when macrophages accumulate too much cholesterol and convert into foam cells that promote atherosclerosis ) since nigella sativa both potentiates macrophage activity yet exerts antiinflammatory effects in these cells at 100µL.

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However, one trial in healthy older adults with similar doses as before (720mg EPA and 280mg DHA) has noted a suppressive effect associated with EPA (and the omega-6 fatty acid GLA) but not DHA.

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