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Long-term skeletal effects of recombinant human growth hormone (rhGH) alone and rhGH combined with alendronate in GH-deficient adults: a seven-year follow-up study.

Reduced bone mineral density is commonly seen in GH-deficient children, and has been noted in disorders of estrogen resistance and aromatase deficiency.

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Differences in persistence, safety and efficacy of generic and original branded once weekly bisphosphonates in patients with postmenopausal osteoporosis: 1-year results of a retrospective patient chart review analysis.

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Some people who take ibandronate sodium tablets develop severe bone, joint, or muscle pain.

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To facilitate delivery to the stomach, and thus reduce the potential for esophageal irritation, Ibandronate Sodium Tablets should be swallowed whole with a full glass of plain water (6 to 8 oz) while the patient is standing or sitting in an upright position.

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Analysis of studies investigating whether baseline turnover markers can predict the bone density changes in patients treated with antiresorptive drugs has been controversial.

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Various interventions are available to decrease the morbidity, mortality, and economic impact of age-related osteoporosis.

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Thus, there is a substantial difference in the hematologic response to initial treatments with pamidronate and ibandronate.

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Rennert and colleagues (2011) noted that bisphosphonates are commonly used for the treatment of osteoporosis and bone metastases caused by breast cancer and were recently reported to be associated with a reduced risk of breast cancer, possibly acting through the mevalonate pathway, but their association with risk of other cancers is unknown.

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The tumor and treatment characteristics of the patients in the two study groups were well balanced ( Table 1 Characteristics of the Patients at Baseline.

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Treatment with these drugs is usually begun after diagnosis of osteoporosis.

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As long as principles of safe movement are followed, walking and daily activities, such as housework and gardening, are practical ways to contribute to maintenance of fitness and bone mass.

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Side effects that can occur in a minority of people shortly after receiving an IV bisphosphonate include flu-like symptoms, fever, headache and pain in muscles or joints.

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and neither iv nor oral ibandronate has been shown to decrease nonvertebral fractures

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Body JJ, Diel IJ, Lichinitser MR, Kreuser ED, Dornoff W, Gorbunova VA, Budde M, Bergström B, and the MF 4265 Study Group (2003) Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases.

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