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Here, we cloned the human K6a promoter, and using a cell-based reporter gene assay, a chemical library was screened for K6a inhibitors.

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The reaction mixture was diluted with CH 2Cl 2 and water and the organic layer was separated, washed with aqueous NH 4Cl, dried over Na 2SO 4, filtered and concentrated in vacuo.

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Mutations in K17 alone, an unpaired accessory keratin, result in the PC-2 phenotype (MIM 184500).

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