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My neurologist had me try many different medications for migraines including Amitriptyline, Topamax and Cymbalta. I was not comfortable with taking medications that are meant to help individuals with seizure disorders and depression. In addition, these medications did not stop the migraines and I experienced many side effects including nausea and decreased appetite. Then I tried Inderal, a low dose medication used to lower blood pressure, paired with B2. My migraines are now fewer and less severe. I still keep Imitrex with me wherever I go to tackle a migraine but I have found that Inderal was the most successful medication that I have tried. Just be sure to take it as recommended. I hope that it helps other migraine sufferers.