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Potentially adverse effects may be due to induction of neoangiogenesis by the hormone, since erythropoietin increases inflammation and ischemia-induced neovascularization by enhancing the mobilization of endothelial progenitor cells.
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III randomized, double-blind placebo-controlled study in subjects with unresectable stage III NSCLC who have demonstrated either stable disease or objective response following primary chemo-radiotherapy (concomitant or sequential).
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He also serves on the boards of HeartWare, BioSphere Medical, Gemin X Biotechnologies and Resolyx Pharmaceuticals.
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Patients who are enrolled and randomized to the Epoetin arm will remain on their current dose and frequency.
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Some of the adverse events reported are typically associated with CRF, or recognized complications of dialysis, and may not necessarily be attributable to Aranesp ä therapy.
Between 1998 and 2004, 175 cases of PRCA were associated with the Eprex formulation containing polysorbate 80.
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