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With Narcotics, Alcohol or Barbiturates it increases the risk of orthostatic hypotension.

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Administer an antiemetic by intramuscular injection when the client complains of nausea and vomiting.

Pathophysiology and Treatment of Resistant Hypertension: The Role of Aldosterone and Amiloride-Sensitive Sodium Channels.

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In the elderly, the agents which most commonly cause this are non-steroidal anti-inflammatory drugs, but sympathomimetics, some immunosuppressants (tacrilimus, cyclosporine), and steroid hormones may also be responsible.

Patients treated with ACE inhibitors who began taking spironolactone after RALES were, on average, 13 years older than the patients who were enrolled in RALES.

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