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Study 6 was a randomized, open-label, controlled study conducted in 522 patients with primary squamous cell carcinoma of the head and neck receiving radiation therapy alone (no chemotherapy) who were randomized to receive darbepoetin alfa to maintain hemoglobin levels of 14 to15.
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The authors concluded that the risks associated with these agents outweigh their benefits for the treatment of CRF and therefore are not to be used.
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