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The triamterene component exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen ions.

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The risk increases with conditions such as sepsis, dehydration, excess alcohol intake, hepatic impairment, renal impairment, and acute congestive heart failure.

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The safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women.

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One study showed that people taking diuretics for more than six months had dramatically lower blood levels of folic acid and higher levels of compared with individuals not taking diuretics.

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Chronic diuretic therapy with moderate doses of triamterene is not associated with folate deficiency.

Overall, evidence from several prospective observational studies and one clinical trial supports the use of kidney stones as an outcome criterion to establish dietary adequacy of potassium.

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Triamterene and hydrochlorothiazide tablets, USP are also indicated for those patients who require a thiazide diuretic and in whom the development of hypokalemia cannot be risked (e.

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Do not use potassium supplements or other diuretics while you are taking triamterene.

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A generic medication is an exact copy of a brand-name medicine, it has the same route of administration, dosage, intended use, side effects, safety and strength.

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