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Donepezil for dementia due to Alzheimer's disease".
Four systematic reviews and one new trial met the guideline eligibility criteria.
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Although in most cases, these effects have been mild and transient, sometimes lasting one to three weeks, and have resolved during continued use of donepezil hydrochloride, patients should be observed closely at the initiation of treatment.
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In these studies, animals were randomly assigned to receive intrathecal saline, the nicotinic antagonist mecamylamine, 50 μg, or a combination of this dose of mecamylamine and atropine, 3 μg, 30 min after oral donepezil, and withdrawal threshold was determined 30 min later (1 h after donepezil).
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Foster received personal compensation for speaking and serving on the Scientific Advisory Board for Myriad Pharmaceuticals and GE Healthcare.
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Donepezil is largely metabolised by the cytochrome P450 isoenzymes 3A4 and 2D6, and undergoes extensive first-pass metabolism.
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However, the proportion of patients fully able to complete the SIB was 25% in the placebo group and only 21% in the donepezil group.
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Bob: We all feel pressured to "do something" for our patients with Alzheimer disease, but sometimes nonaction is the best course.
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