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The serotoninergic neurons project from the dorsal raphe nucleus to the medial basal hypothalamus and exert their action via 5HT1A and 5HT2 receptors mechanisms; Paraventricular Nucleus (one of the prominent nuclei of the Medial Hypothalamus), proved by pharmacologic and anatomic data to be a major regulatory site of serotonin-induced prolactin release, contains different populations of neurosecretory cells, producing oxytocin, vasopressin, vasoactive intestinal peptide (VIP), thyreotropin releasing hormone (TRH) and other neuropeptides.
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Schizophrenia usually starts in late adolescence or early adulthood, and may be preceded by years of gradual social and academic deterioration.
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It combines the advantage of previously available depot formulations for first-generation drugs with the favorable characteristics of the modern “atypical” antipsychotics, namely higher efficacy in the treatment of the negative symptoms of schizophrenia and reduced motor disturbances.
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