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I (78 y.o. male) was diagnosed with NSCLC in March 2011 and in late May I started taking Iressa as a first line of treatment. For the first five months my only side effect was a mild rash. I then had swollen gums and stomach acid. Both quickly responded to antibiotics. 75 days between the March and May CT scans the tumor increased by 86% (from 4.9 x 4 cms). 50 days later in July, after taking Iressa, the CT scan revealed an 83% reduction. From March to July it reduced by 69% and in December, although subtle, there has been further reduction.
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Stephen V Liu, Deepa Subramaniam, George C Cyriac, Feras J Abdul-Khalek, Giuseppe Giaccone.
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Evidence of a modest increase in survival in patients with better PS given high-dose EBRT is available.
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None of the six assessable patients treated with gefitinib who had a KRAS-positive mutation had a tumor response (response rate, 0%; 95% CI, 0 to 39.
We also assessed MET amplification using quantitative PCR, and it did not differ significantly among the groups (Fig.
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NSCLC receiving 3rd- and 4th-line chemotherapy showed that response rates decreased with each successive chemotherapy regimen, as follows: 1st line, 20.
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Increased levels of MRP1 and MRP3 mRNA expression were observed, but MRP2 mRNA expression was not affected (Fig.
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In 1987 he joined the US National Cancer Institute where he worked until 1996, when he was appointed as Professor of Oncology at Queen's University Belfast.
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Intrathecal chemotherapy treats subclinical leptomeningeal deposits and tumor cells floating in the CSF, preventing further seeding.
Although the original clinical trial was designed to address the clinical question regarding the combination of gefitinib treatment with anastrazole (), this work is focused on trying to understand the cellular mechanism involved in the response to EGFR inhibition.
Many of the sensitizing mutations have been detected in tumors from drug responders.
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