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In this study, we investigated the antiepileptic properties of ranolazine using hippocampal neuronal cultures.

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In an ischemia-reperfusion-isoproterenol model of AF, 5 μM ranolazine was observed to prevent the induction of AF in 60% of atrial preparations.

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Exercise treadmill tests were performed at the end of each study period to coincide with peak (4 hours) and trough (12 hours) plasma levels.

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All study participants underwent comprehensive 2-dimensional (2D) echocardiographic examination with Doppler and tissue Doppler imaging (TDI) at rest and at peak bicycle exercise using a commercially available exercise ergometer (MPI; Medical Positioning, Kansas City, MO) at both the baseline and 3-month study visits.

Ranolazine, a novel agent for chronic stable angina.

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Molecular Pharmacology 2014-01-01 Ranolazine reduces neuronal excitability by interacting with inactivated states of brain sodium channels.

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The effects of R compared to control on heart rate and blood pressure were also analyzed.

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In the active drug arm each patient will be started on a 500 mg twice a day dose for one week with subsequent increase to 1000 mg twice a day at beginning of second week.

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Ranolazine should be used in combination with amlodipine, β-blockers, or nitrates.

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