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While intravenous therapy may be preferred for patients with severe infections, comorbid conditions, or gastrointestinal malabsorption, oral fluoroquinolones are readily bioavailable in the absence of drug interactions or the aforementioned conditions.

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These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.

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Concomitant use should be avoided unless the necessity for tizanidine therapy is clinically evident.

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Yet another aspect of this invention is providing information to prescribing physicians and patients receiving tizanidine therapy useful in limiting somnolence as a side effect when taking tizanidine in immediate release multiparticulate or tablet dosage form.

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Some orally ingested triptans are significantly metabolized by hepatic first-pass, affecting eventual drug blood levels.

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