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Because the controlled trials performed during premarketing development all used a titration design, with a resultant confounding of time and dose, it was impossible to adequately evaluate the effects of dose on the incidence of adverse reactions.
Although monoamine synapses are believed to be the immediate targets of antidepressant drugs, more attention is given to the target neurons of monoamines, where chronic alterations in monoaminergic inputs caused by antidepressant drugs presumably lead to long-lasting adaptations that underlie effective treatment of depression.
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Experimental and clinical studies have provided evidence that activation of the D2 receptors is important in mediating the beneficial antiparkinsonian effects of DA agonists, but concurrent D1 and D2 stimulation is required to produce optimal physiological and behavioral effects () ().
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Horizant is FDA-approved for RLS.
Dopaminergic drugs include dopamine precursors and dopamine receptor agonists.
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