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Although not directly tested in this trial, we speculate that varenicline's effectiveness in smoking cessation results from its proposed dual mechanism of action.

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For sensitivity analyses, we used inverse variance methods under fixed and random effects models for the outcomes with the largest number of treatment events; random effects models can be problematic for meta-analyses of rare events.

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varenicline is a partial agonist of the subtype of neuronal nicotinic receptors composed of

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Accordingly, the subject invention pertains to the techniques we have developed to control the synthesis of varenicline drug substance to insure that levels of the noted impurities are at acceptably low levels, including the preparation of synthetic standards for the optimization of the processes leading to varenicline, and pharmaceutically acceptable salts thereof.

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Varenicline, the most recent Food and Drug Administration-approved smoking cessation aid, and the first in a class of α4β2 nicotinic acetylcholine receptor (nAChR) partial agonists, came to market in 2006.

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In doing so, it presents general concepts that can aid prescribers in avoiding untoward DDIs when possible, and quickly recognizing them when they occur.

Randomised controlled trials have shown it to be the most clinically effective drug for short term abstinence in smoking cessation.