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Localized symptoms are most common during the first few days of tacrolimus ointment application and typically improve as the lesions of atopic dermatitis resolve.

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However, at currently recommended doses, tacrolimus shares many side effects with cyclosporine, including nephrotoxicity, neurotoxicity, infectious complications, and disturbances in lipid metabolism.

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While a limited sampling strategy using 2 time points is more reliable and accurate, its performance changes according to post transplantation time, which may cause practical difficulties when performing therapeutic monitoring of tacrolimus in these patients.

Muromonab-CD3 is sometimes used as the first-line agent for severe vascular rejections.

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If the reaction abates, restart infusion at 50% of the previous rate.

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Results: In total 4852 samples that were positive for EtG in the screening at the routine reporting limit (0.

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First-line antibody therapy was permitted only if biopsy indicated a severe vascular rejection (Banff IIB or III).