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Assess disability and cognition regularly, both by the patient self-reporting (eg, time how long it takes the patient to walk 20 yards; whether the patient can dress alone; whether he or she can turn over in bed) and by objectively rating motor symptoms (as in the Unified Parkinson's Disease Rating Scale).

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Prominent autonomic dysfunction, especially frank urinary incontinence or profound orthostatic hypotension, may suggest (MSA) rather than Parkinson disease.

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Third, to examine the possibility of channeling bias where the choice of medication might be influenced by a history of pneumonia or prior use of anti-parkinsonian medication, we carried out analyses stratified by history of pneumonia prior to cohort entry and by the type of anti-parkinsonian medication received prior to the 180-day period before the index date.

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