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I was put on topamax for about 3 weeks for excruciating migraines that I would get just about daily. While it was pretty effective at decreasing my headaches (I only had about one or two in the three weeks I was on it), I experienced side effects from it. I was taken off it for a few days and then put back on to see if I still had the same problems. A little bit of lip tingling but nothing major. When I upped the dose like I was supposed to my gums started hurting so my doctor took me off it and put me on Depakote.
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In Study 1, a total of 469 patients (416 females, 53 males), ranging in age from 13 to 70 years, were randomized and provided efficacy data.
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The primary treatment of cases of secondary angle closure glaucoma cause by topiramate (the active ingredient contained in Topamax) is discontinuation of the drug.
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It is also an inhibitor of carbonic anhydrase, particular subtypes II and IV, but this action is weak and unlikely to be related to its anticonvulsant actions, but may account for the bad taste and the development of renal stones seen during treatment.
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The ones who took topiramate plus CBT experienced greater weight loss and a higher rate of abstention from binging during treatment.
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