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For me Prednisolone is a wonderful drug, actually the only one that helps me forget about severe pain that I had for years because of my eczema. It was real hell for me all that time when I've been trying to find a solution among different useless topicals and creams. At first the disease started without any reason. One day my palms became itchy, at first I paid little attention. But the itching wouldn't stop and I used to scratch the palms to bleeding. Tried moisturizing creams - no use. And then gradually the skin on my palms turned to be very thin and dry and consequently I started getting occasional cracks, very painful and annoying. I couldn't do anything from my usual housework without gloves; taking shower was a trial as the pain afterwards was horrible. I visited many different doctors before I got a diagnosis, nothing to say about effective treatment. When finally my new doctor told me that the disease could have developed due to a hormonal shift caused by some immune system changes and prescribed me with Prednisolone I had little hope. But luckily the doc was right! Prednisolone caused almost immediate change for the better. I have been on the medication for about two months now and my palms are not that dry anymore, I get only minor cracks when I forget to use gloves or don't take Prednisolone for a while. I'm happy as never before, such a great relief it is!