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I have been taking Remeron for a month now for depression, anxiety, loss of appetite and insomnia. I have experienced a red swelling burning sensation in my face and neck - almost like a sunburn, painful, lasting at least two days then still feeling a little sensitive in my face and neck. My sleep is better, however there are still nights when it takes me a couple of hours to fall asleep, other times I go out like a light. My appetite is better and I am not as anxious anymore. I have tried many other anti-depressants and Remeron(30mg) is the best for me by far. I only hope that the face problem goes away. I did read a comment here by someone who was experiencing facial edema. In the monograph it does allude to this.