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I am soon to be 49 and I was feeling so bad, hotflashes, 30 pounds of weight gain in 2 yrs, insomnia, foggy brain and a very large appetite, to name a few right but saw a doctor (alternative) and he did blood work and found my testosterone was so low and my progestin. So I now take a small dose of testosterone cream and 200 mg of natural progestin and can I tell you I feel like I did in my 30's. Use progestin at night, testosterone in the morning. I have lost 12 pds in about 40 days and it continues to fall off. Sleeping like a baby, no hot flashes and I think more clearly and my memory is awesome too. I do take a lot of supplements that work with the hormones.