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Due to the absence of significant hepatic metabolism, varenicline pharmacokinetics should be unaffected in patients with hepatic impairment.

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Because altered locomotor activity can confound results both in the NIH test and in the marble-burying test, treatment effects on locomotor activity were evaluated.

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In 12 trials losses to follow-up were higher in the varenicline group than the placebo group, whereas in 17 trials losses to follow-up were higher in the placebo group than the varenicline group.

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Equation 2 illustrates that drug concentration is a function of the dosing rate the patient is taking relative to their ability to clear the drug.

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