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Hemorrhagic stroke the first 30days after an acute myocardial infarction: Incidence, time trends and predictors of risk.

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For example, metronidazole and clarithromycin are considered the "backbone" of most HP regimens, however in vitro resistance to these antibiotics has been reported to be as high as 40% and 13% respectively.

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San Diego, Calif), or the Multiplate Analyzer (Dynabyte Medical), which was used in this study, have been developed.

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However, the role of long-term combined therapy with aspirin and an antiplatelet agent in a broader group of patients at high risk for cardiovascular events is unknown.

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In addition, the risk of bleeding increases additionally when interventions, especially coronary bypass surgery, are performed in the presence of these drugs.

Apart from decreasing rebleeding rates and mortality in acute bleeding in peptic ulcer disease, proton pump inhibitors (PPI's) have also shown to decrease the symptoms, decrease mortality increase quality adjusted life years and shown to be cost- effective for GERD (3) More than 60 million prescriptions for GERD were estimated to have been filled at retail pharmacies in 2004 (2).

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For a hypothetical group of 1000 men younger than 60 years with a 6% 10-year baseline risk for myocardial infarction, aspirin use will prevent approximately 19 myocardial infarctions and cause approximately 1 hemorrhagic stroke and 8 major bleeding events ().

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The increased risk of cardiovascular events was similar among all PPIs studied (omeprazole, esomeprazole, pantoprazole, and lansoprazole), with the highest rate of cardiovascular events occurring among patients taking pantoprazole.

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