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Specifically, there are a number of compounds that decrease the circulating availability of fatty acids ( 1), protein-mediated uptake of fatty acids ( 2), mitochondrial uptake of fatty acids ( 3), and fatty acid β-oxidation directly ( 4) and indirectly ( 5).

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Giorgio Minotti, CIR and Drug Sciences, University Campus Bio-Medico, Via Alvaro del Portillo, 21, 00128 Rome, Italy.

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Furthermore, in a recent study Gadicherla et al showed that in hearts exposed to global ischemia, the addition of ranolazine on reperfusion improved mitochondrial complex I activity, restored electron transfer through Fe-S clusters of complex I, and preserved supercomplex assembly and cardiolipin integrity.

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The efficacy end points included treadmill exercise duration, time to angina, time to 1 mm ST-segment depression at peak and trough, and the number of angina attacks and sublingual nitroglycerin uses reported by the patients.

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To put it differently generics have identical active ingredients and their pharmacological effects are the same, as those of their brand-name equivalents.

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