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The LIFE study was a multinational, double-blind study comparing Losartan potassium and atenolol in 9193 hypertensive patients with ECG-documented left ventricular hypertrophy.

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In addition, both the and nervous systems can use angiotensin for sympathetic neurotransmision.

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Comparing angiotensin II receptor blockers on benefits beyond blood pressure.

Although the pharmacokinetic and pharmacodynamic properties of olmesartan suggest that at its starting dose, it should compare favorably with ARBs already in clinical use for the treatment of hypertension, a direct comparison of the efficacy of these agents can be determined only in a head-to-head trial.

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Blood pressure and pulse, adverse events, concomitant medications, and adherence to medication regimens were assessed at each visit.

The following additional adverse reactions have been reported in postmarketing experience with Losartan.

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All efficacy analyses were performed on the intent-to-treat population, defined as any patient who had received at least one dose of study medication after randomization, and for whom baseline data and at least one postbaseline measurement were available.

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Fluconazole, an inhibitor of cytochrome P450 2C9, decreased the AUC of the active metabolite by approximately 40%, but increased the AUC of losartan by approximately 70% following multiple doses.

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Inhibition of angiotensin II binding to AT1 inhibits its AT1-mediated vasoconstrictive and aldosterone-secreting effects and results in decreased vascular resistance and blood pressure.

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Consider specific co-morbidities and disease aetiology when treating hypertension in patients with chronic kidney disease.

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