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Safety and tolerability of pazopanib in the treatment of renal cell carcinoma".

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The JNK inhibitor, SP600125, attenuated the gefitinib-induced cytotoxicity and apoptosis of HaCaT cells.

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He and his family strongly desired the readministration with gefitinib rather than palliative care.

By 1996, clinical trials had expanded to over 900 women, but due to pressure from advocates based on early success, Genentech worked with the FDA to begin a lottery system allowing 100 women each quarter access to the medication outside the trials.

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Total RNA purified from two-independent cultures of DMSO passaged control and gefitinib-resistant cultures of HCC4006 cells and HCC827 cells was used to prepare cDNA for sequencing with the Illumina Genome Analyzer IIx using the Illumina mRNA sequencing preparation kit (San Diego, CA, USA).

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In particular, LKB1 genetic alterations have been frequently detected in NSCLCs as compared with small cell lung cancers and are significantly more frequent in cancer cell lines with KRAS mutations, occurring in a subset of poorly differentiated lung adenocarcinoma that appear to correlate with smoking males ().

Although the majority of EGFR mutants were more sensitive to gefitinib by measuring receptor Tyr phosphorylation, it does not warrant hypersensitivity at the cellular level.

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For questions about nucleotide positions, please contact the directly, as they are the authoritative source on cytochrome P450 nomenclature.

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We report the case of gefitinib readministration in a patient with lung adenocarcinoma who had once responded but in whom treatment had to be discontinued owing to gefinitib-related ILD.

L- Asperginase is used to starve cancer cells by breaking down an amino acid called Aspergine, which is essential for their rapid growth.

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From this concern, if similar mutation exists in carcinoma of esophagogastric junction, the TKI therapy to carcinoma of esophagogastric junction will be promising.

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