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Biopsy specimens were obtained from representative areas from all patients before and after treatment.

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Imiquimod cream should be applied prior to normal sleeping hours and left on the skin for 6 -10 hours, after which time the cream should be removed by washing the area with mild soap and water.

Over the past several years, there have been reports in the medical literature and from medication safety centres around the world concerning adverse events with fentanyl transdermal systems (also referred to as fentanyl “patches”).

Of 14 lesions that regressed to grade 1 vulvar intraepithelial neoplasia or to no neoplasia, 13 were cleared of HPV after treatment with imiquimod and the other lesion was HPV-negative at baseline.

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Sufficient cream should be applied to cover the treatment area (including a 1 cm margin of skin around the tumor) and it should be rubbed in until the cream disappears.

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Grossman and Leffell 2 explain that UV radiation is involved in the pathogenesis of AKs through inducing cellular DNA mutations in the skin, which may affect cell proliferation genes, such as p53 and ras, or prompt evasion of apoptosis.

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About 69% of metastases are diagnosed within 1 year, 91% within 3 years, and 96% within 5 years.

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Although not evaluated in this study, differences in expression levels of TLRs or other receptors that interact with Leishmania, the maturation stage (), and the functional integrity of permanent cell lines () may account for differences observed in the responses to parasite opsonization elicited in primary macrophages and macrophage cell lines.

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More-less general consensus is that Picato doesn't help if AK or cancer (specially cancer) goes bit deeper (and most of them do).

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