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Although a short-term benefit of cyclosporine in active Crohn's disease has been suggested, the long-term safety and efficacy of this treatment have not been established.
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Produces nephrotoxic effects, which generally appear to be dose dependent and reversible.
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This is thought to occur through suppression of inflammation by cyclosporine on the ocular surface.
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serum creatinine improved in all but one patient after discontinuation of cyclosporine
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The major side effect of systemic CsA is nephrotoxicity that is reversible with dosage reduction.
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Clinical remission rates at both week 30 and 54 were significantly higher in the golimumab 100 mg group compared to the placebo group (27.
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For this reason, several pharmacodynamic assays have been developed in human medicine in an attempt to better estimate the dosage of cyclosporine needed to maintain immunosuppression and prevent organ rejection in individual transplant patients while minimizing the expense and adverse effects associated with excessive drug dosages.
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Additional medication to relieve side effects was rarely needed in either group.
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Patients with scores below 150 are considered to have inactive disease.
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