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Despite the withdrawal of 9 subjects from a relatively small sample size, intention-to-treat analysis still revealed a significant difference in measured outcomes as described above.

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When imiquimod was compared with any other patient-applied treatment, we were unable to determine whether it led to differences in the rate of complete or partial regression, recurrence or the presence of local reactions, although systemic adverse reactions were lower in the imiquimod group.

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Dal punto di vista teorico le interazioni con farmaci sistemici dovrebbero essere alquanto limitate in considerazione dello scarso assorbimento cutaneo di imiquimod applicato come crema.

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EGW was observed with once daily dosing for 3 weeks in all subjects.

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