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Sulfonylureas cause a closure of potassium channels and depolarization of the cell membrane.

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Drinking can be harmful when taking certain over-the-counter and because alcohol intensifies the effect of some pain medicines.

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If patients have not responded to 4 weeks of the maximum dose of GLUCOPHAGE or GLUCOPHAGE XR monotherapy, consideration should be given to gradual addition of an oral sulfonylurea while continuing GLUCOPHAGE or GLUCOPHAGE XR at the maximum dose, even if prior primary or secondary failure to a sulfonylurea has occurred.

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The mean age of the population was 59 years and 4% were older than 75 years.