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My cardiologist diagnosed me with stable angina about a year ago. At that time I experienced tightness in my chest and pain when breathing after some exercises. That considerable spoiled my life as I enjoy climbing and often stay in the mountains with my friends. He put me on some medication and the on second day of taking it I developed some itching and rash on my arms. However I decided that was from mosquitoes or some strange food and paid no attention and naturally continued on the medication. The rash wouldn't disappear and having come back home I visited a dermatologist. He said it was not a skin disorder and probably some intolerance of a new drug. I went to the cardiologist again and he told me to stop taking the medication and prescribed Ranolazine. With this med I had no itching or rash. The angina also created considerably less problems that before. No I could control the pain and had no more problems with breathing. It's been two months since I have started on Ranolazine and I am absolutely ok with it.
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I've been taking it for three months. I haven't used a nitro in that time. The chest pain I experienced in breathing cold or humid air, or after climbing, or even after stress has dissipated to an unexpected and happy extent. However, the side effects are bothersome, though not insurmountable. Dry mouth, almost continuously, which sometimes affects ability to speak clearly. Constipation, overcome by hard bowel movements, use of stool softeners. And just a general feeling of stuffiness, in body, in sinuses, elsewhere. Hard to say whether I would recommend it. The annoyances at times are major; the feeling of freedom from the chest pain and fear greatly offset the annoyances so far. Incidentally, I am 77, with only one open artery.
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Author Contributions: Wrote the first draft of the manuscript: MA.
Thus, both the mechanism of action and the effects of ranolazine are different from those of currently available anti-anginal and anti-ischaemic drugs.
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Further, it is likely that ranolazine plasma concentrations must be maintained at or above the threshold value throughout the dosing interval to ensure antianginal and anti-ischemic activity during exercise throughout this interval.
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