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I have had CHRONIC cluster headaches since 1978. Of the dozens of medications I have been prescribed, the only one that has brought me sustained relief over the years is Cyproheptadine. I have been on it since 1984, 8-mg twice a day every day (except during my pregnancies when I stopped all medicines, reverting to indescribable pain). My cluster headaches are not cured by cyproheptadine, but the severity of pain is reduced to a tolerable level. No side effects. Also, I had an occipital nerve stimulator implanted in 2007, which continues to help tremendously. Best abortive for me has been Ultram, 3 tablets taken at onset of pain (I try to limit this to 1 or 2 times per day, taken at the times I most need to function well).
I was prescribed 4 mg 3x a day. I asked my PCP for a prescription for this after doing some research myself. I never did see clear dosage guidelines so my Dr put me on the dose for allergies because use for migraines its off lable. I started it at 4 mg at night and had to go home sick (sleepy) from work the next day! So be very cautious when starting this medicine. I then started taking only 2mg each night and it has worked wonderfully. I had a migraine everyday for about 6 months before trying this and now not one for Months. I feel like I have my life back.
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