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I have chronic panic disorder with agoraphobia and due to the fact I have not responded to any antidepressant and have only had a moderate response with benzodiazepines (I was taking Xanax XR) I spoke to my doctor about trying Miltown (meprobamate), the first anxiolytic in history, just to see if it can help. I take 400 mg four times a day (1,600 mg) and I have, to my surprise, actually found it to be fairly effective. I was particularly surprised due to its low potency, 0.5 mg of Xanax is considered bioequivalent to 1,400 mg of Miltown. It takes longer than Xanax, Ativan, or Valium to work and I have noticed I can "feel" when Miltown starts to work where as I did not with benzodiazepines (bad). Good novel treatment.